Ketamine: Effects, Medical Uses, Risks

effects of ketamine on humans

Status epilepticus is when a person has a seizure that lasts longer than 5 minutes or has more than one seizure within 5 minutes. Additionally, ketamine has been abused to facilitate sexual assault. Ketamine is also used for anesthesia in a range of veterinary procedures, such as for dogs, cats, and other animals.

Dosage and Administration

In contrast, no recreational use of the drug is safe, as it can cause addiction and adverse health effects that can lead to death. Because several other trials indicate ketamine may have significant antianxiety effects, the authors encouraged future studies to explore this possible benefit more fully. A 2016 study cautions that the inappropriate use of ketamine is a worldwide health problem due to its hallucinogenic properties. With this in mind, they urge doctors to prescribe standard antidepressants before trying celebrities with fetal alcohol syndrome ketamine for depression. Despite these positive results, the authors warn that data on the use of ketamine for this condition are limited, so practitioners should consider the risks of the drug before prescribing it.

This medication is considered safe and may reduce the need for post-operative pain medication. Before Spravato was approved in 2019, ketamine was prescribed off-label for the treatment of harbor house sober living depression. Other off-label uses of ketamine include treating bipolar disorder, post-traumatic stress disorder, as well as substance use disorder.

Because of its pain-relieving and mental effects, it can cause dependence, the need to take higher doses to get the same effect, and addiction. People who use it claim that a ketamine trip is superior to a PCP or LSD trip because it produces shorter-term hallucinations that last 30 minutes to an hour instead of several hours. Keep reading to learn more about the uses, side effects, and risks of ketamine, as well as its interactions with alcohol and other drugs.

Treating depression

Both alcohol and ketamine are central nervous system depressants, so the combined effects are dangerous. If you are having surgery, you might receive ketamine as one of your anesthetic medications. As you wake up from your surgery, the effects of ketamine are among the reasons why you won’t remember the procedure.

In an emergency? Need treatment?

Please contact AAC free at for more information on treatment options, helpful advice, or admissions. Ketamine is typically injected or snorted, but it can be smoked or taken in helpstay reviews pill form. The effects of smoking it or swallowing it tend to be less intense than those of directly injecting it. In some cases, it’s used as a date rape drug, as it’s odorless and colorless. Seeking help for addiction may feel daunting or even scary, but several organizations can provide support. Evidence shows that ketamine is safe for use in people within a wide age range when taken correctly.

There’s one other actor in this play that’s important to mention, which is esketamine. Ketamine and esketamine are chemically very similar, but they’re two different drugs. Ketamine is only FDA-approved as an anesthetic, and is still widely used for anesthesia and acute pain in surgical, operative, and emergency trauma settings. Esketamine was brought to market around 2019 for the management of treatment-refractory depression [depression not responsive to standard treatment]. Ketamine is used as an anesthetic for surgery, a treatment for depression, and is a drug of abuse. Ketamine is FDA-approved as an anesthetic to put you to sleep for surgery and to help prevent pain and discomfort.

Ketamine is injected intravenously (IV) or intramuscularly (IM, in a muscle) when used for surgery. It is typically used for anesthesia induction before other anesthetic drugs are administered. Ketamine is an injectable anesthesia that has been used in humans and animals since 1970.

In our experiments, we separated the ketamine infusion from the induction of general anesthesia for the surgery, during which a different anesthetic, propofol, was used. You may also have experienced severe side effects but still be taking the drug. Alternatively, you might be committing illegal or morally questionable acts because of it. However it manifests itself, if you have an addiction to ketamine, you need to seek help.

Amphetamines should never be mixed with ketamine because they can cause very high blood pressure. It starts around 2 to 5 minutes after the dose has been smoked or swallowed. With injection, it happens around 30 seconds after the injection has occurred. Ketamine can also produce an extensive array of other symptoms that affect many parts of the body, but they are less common.

  1. Despite these positive results, the authors warn that data on the use of ketamine for this condition are limited, so practitioners should consider the risks of the drug before prescribing it.
  2. PTSD, or possibly severe generalized anxiety disorder, might fit that bill.
  3. It’s hard for users to tell whether they’ve injured themselves, so they can end up hurting themselves severely.
  4. Depression, anxiety, post-traumatic stress disorder, and chronic pain are the big ones, but it’s also being marketed for other uses, ranging from Lyme disease to alcoholism to opioid addiction.
  5. Aside from the above drug interactions, a 2017 study reports that taking ketamine with amphetamine-like stimulants can produce undesirable effects.
  6. Most surgeries also require anesthetics that reduce muscle tone and movement.

This minimizes the need for close medical supervision throughout the period of withdrawal—allowing those in recovery to move forward and focus on the second stage of their treatment. This is a drug that should be administered in highly controlled, highly supervised, structured clinical settings. But it’s being used in a lot of different settings, the most concerning of which is non-health care settings. In some places, you can get this drug compounded by a pharmacy for in-home use, which is really asking for trouble. These clinics can purchase a vial for less than $100 and charge $500 to $1,500 for an infusion.

effects of ketamine on humans

Sometimes infusions have been continued once or twice weekly during the continuation phase for a total of 4–6 weeks of therapy or gradually tapered. In clinical trials ketamine infusion therapy dose is lower than an anesthetic dose. If patients have not responded to several initial infusions, then it appears unlikely that they will respond to further infusions. With ketamine, we have a drug that has unclear effectiveness with some very well described dose-response and cumulative adverse effects that run all the way up to death. There is a remarkable dearth of evidence of well controlled, randomized, blinded trials, which really represent the gold standard for how we assess effectiveness. Many trials only look at short-term, not at moderate or long-term, outcomes of effectiveness.

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